Primary Ovarian Insufficiency (POI)

Facing Primary Ovarian Insufficiency can be challenging. Dive deep into the world of POI, its symptoms, and discover how Kindbody assists women on this unique fertility journey.



Roughly 1% of women may be diagnosed with POI.


It's estimated that around 10% of women with POI can still conceive without medical assistance.


Nearly 60% of POI cases have no identifiable cause.
Your POI Questions Answered

While the exact cause of POI remains unknown in many cases, factors might include:

  • Genetic abnormalities or mutations.
  • Autoimmune diseases.
  • Chemotherapy and radiation treatments.
  • Infections that can damage the ovaries.

Though symptoms can vary among women, common signs include:

  • Irregular or missed periods.
  • Hot flashes or night sweats.
  • Vaginal dryness.
  • Difficulty in conceiving.
  • Irritability or difficulty concentrating.

Women with POI often face reduced fertility due to a decreased number of available eggs. However, spontaneous pregnancies can still occur, though they are less common. For many, assisted reproductive techniques, including egg donation, become valuable options.

Yes, it’s possible for some women to have POI without experiencing noticeable symptoms. This can occur if hormone levels remain relatively stable, or if symptoms are mild and go unnoticed. Regular check-ups with a healthcare provider, especially for women experiencing irregular menstrual cycles or fertility concerns, can help detect POI early.

While primary ovarian insufficiency (POI) cannot always be prevented, adopting a healthy lifestyle may help reduce the risk or delay its onset. This includes maintaining a balanced diet, avoiding smoking, limiting alcohol intake, managing stress, and ensuring regular exercise. However, it’s important to note that some cases of POI may be genetic or related to other medical conditions, so prevention strategies may not always be effective.

POI can have a significant impact on mental and emotional health due to its effects on fertility, hormone levels, and overall sense of identity. Women with POI may experience feelings of grief, loss, anxiety, or depression, particularly if they had hoped to conceive. Support from healthcare providers, counselors, support groups, and loved ones can be valuable in navigating the emotional challenges associated with POI.

General Treatment Options

Tailoring treatment approaches to the unique needs of each woman, considerations often revolve around their family building aspirations. Options may encompass:


Hormone Replacement Therapy (HRT)

Balancing estrogen and progesterone levels.


Egg or Embryo Donation

Providing viable avenues for conception.


In Vitro Fertilization (IVF)

Utilizing donor eggs to enhance pregnancy prospects.


Bone density treatments

Mitigating the risks of early bone density decline associated with POI.

When to Consult a Healthcare Provider

If your menstrual cycle has been absent for three months or longer, it’s essential to consult your healthcare provider to identify the underlying cause. While missed periods can stem from various factors like pregnancy, stress, or lifestyle adjustments, it’s crucial to undergo a health checkup whenever your menstrual pattern deviates.

Even if the absence of periods doesn’t concern you, seeking medical advice is advisable to ascertain the root cause. Low estrogen levels associated with disrupted menstrual cycles can contribute to conditions such as osteoporosis, characterized by weakened bones, as well as increase the risk of heart disease. Consulting a healthcare professional can provide insight and guidance tailored to your individual health needs.

Emotional Support for POI at Kindbody

A diagnosis of POI comes with a myriad of emotions. At Kindbody, we understand this journey and provide emotional and psychological support to women, ensuring they never feel alone. Navigating through the complexities of POI might seem daunting, but with the guidance and support of Kindbody’s expert team, women can confidently explore all the available options and pathways to building their families.